Neglected Tropical Diseases (NTDs) remain endemic to many regions of sub-Saharan Africa (SSA) left behind by socioeconomic progress.As such, these diseases are markers of extreme poverty and inequity that are propagated by the political, economic, social, and cultural systems that affect health and wellbeing.As countries embrace and work towards ac
BackgroundQuorum sensing (QS) in Sinorhizobium meliloti involves at least half a dozen different N-acyl homoserine lactone (AHL) Solid signals.These signals are produced by SinI, the sole AHL synthase in S.meliloti Rm8530.The sinI gene is regulated by two LuxR-type transcriptional regulators, SinR and ExpR.Mutations in sinI, sinR and expR abolish t
Background: Herpes simplex virus (HSV) is usually dormant and becomes apparent when body conditions decline.We investigated the anti-HSV activity of various natural and synthetic compounds for future clinical application.Methods: Mock- and HSV-infected Vero cells were treated for three days with various concentrations of samples.For short exposure,
The application of machine learning algorithms to the detection of fraudulent credit Feeding card transactions is a challenging problem domain due to the high imbalance in the datasets and confidentiality of financial data.This implies that legitimate transactions make up a high majority of the datasets such that a weak model with 99% accuracy and
Melanoma, the most aggressive form of skin cancer, presents a major clinical challenge due to its tendency to metastasize and recalcitrance to traditional therapies.Despite advances in surgery, chemotherapy, and radiotherapy, the outlook for advanced melanoma remains bleak, reinforcing the urgent need for more effective treatments.Photodynamic ther